Bibliophile. Writer. Engaged in the quest to seek all knowledge.
History and archeology. Science. Fortean phenomena. Fanfiction fangirl.
Like Dame Helen Mirren, Dame Maggie Smith, Meryl Streep, Hillary Clinton, Sue Johnston, Kelly Rowan, Marina Diamond, Patricia Cornwell, Val McDermid, Lisa Edelstein, Olivia Wilde, Christina Ricci, Captain Janeway
Have a disturbing tendency to obsess over fictional characters...Sam Vimes, Sybil Ramkin, Lord Vetinari (Discworld), Minerva McGonagall (Harry Potter)
"Always bear in mind the fact you might be dead wrong."


(Source: steambunk)
Dr. Patricia Wadsworth
University of Massachusetts
Amherst, MA, USA
Specimen: Mitotic Spindle
Technique: ConfocalWhile the spindle apparatus is composed of hundreds upon hundreds of proteins,the fundamental machinery are the spindle microtubules. Attachment of microtubules to chromosomes is mediated by kinetochores, which actively monitor spindle formation and prevent premature anaphase onset. Microtubule polymerization and depolymerization dynamics drive chromosome congression. Depolymerization of microtubules generates tension at kinetochores, bipolar attachment of sister kinetochores to microtubules emanating from opposite cell poles couples opposing tension forces, aligning chromosomes at the cell equator and poising them for segregation to daughter cells. Once every chromosome is bi-oriented, anaphase commences and cohesin, which couples sister chromatids, is severed, permitting the transit of the sister chromatids to opposite poles.